Dietary supplements and nutraceuticals are also disclosed in Physicians ' Desk Reference for Nutritional Supplements, 1st Ed. If the non-fluticasone active agent has a nanoparticulate particle size i.e, a particle size of less than about 2 microns, then preferably it will have one or more surface stabilizers associated with the surface of the active agent, hi addition, if the active agent has a nanoparticulate particle size, then it is preferably poorly soluble and dispersible in at least one liquid dispersion media. Prevention of the growth of microorganisms can be ensured by various antibacterial and antifungal agents, such as parabens, chlorobutanol, phenol, sorbic acid, and the like. This is because nanoparticulate fluticasone compositions benefit from the small particle size of fluticasone; if the nanoparticulate fluticasone particles do hot redisperse into the small particle sizes upon administration, then "clumps" or agglomerated fluticasone particles are formed. Such biorelevant aqueous media can be, for example, aqueous electrolyte solutions or aqueous solutions of any salt, acid, or base, or a combination thereof, which exhibit the desired pH and ionic strength. Bioadhesive nanoparticulate compositions were first described in U. Proper fluidity can be maintained, for example, by the use of a coating such as lecithin, by the Attorney Docket No. " 5,326,552 for " Novel Formulation For Exemplary nutraceuticals and dietary supplements and The Physicians ' Desk Reference for Herbal Ri^ are CH3, one of Ri^ is C6H5CH2, and one of R1-R is an alkyl chain of seven carbon atoms or less; (vi) two of R1-R are CH3, one ofRι-R4 is C6H5CH2, and one ofRι-R is an alkyl chain of nineteen carbon atoms or more; (vii) two of R1-R are CH3 and one of Rι-R is the group C6H5(CH2)n, where n>l; (viii) two of R1-R are CH3, one of R1--R4. The period of time in which a biological cell surface is replaced is the factor that limits retention of the bioadhesive fluticasone particles to that biological surface. Process of Preparing X-Ray Contrast Compositions Containing Nanoparticles;" U. In vitro assays using human lung cytosol preparations have established fluticasone propionate as a human glucocorticoid Attorney Docket No. Article Showcase. Category: Herbals Expert! It is emphasized that 'therapeutically effective amount,' administered to a particular subject in a particular instance will not always be effective in treating the diseases described herein, even though such dosage is deemed a 'therapeutically effective amount' by those skilled in the art. Such excipients include various polymers, low molecular weight oligomers, natural products, and surfactants. Such a method comprises dispersing fluticasone particles in a liquid dispersion medium in which fluticasone is poorly soluble, followed by subjecting the dispersion to homogenization to reduce the particle size of the fluticasone to the desired effective Attorney Docket No. Shop the latest products from Naturogenix: Natural Supplements and therapies on Wanelo, the world's biggest shopping mall. Shop the latest products from.. Exemplary nutraceuticals or dietary supplements include, but are not limited to, lutein, folic acid, fatty acids (e.g, DHA and ARA), fruit and vegetable extracts, vitamin and mineral supplements, phosphatidylserine, lipoic acid, melatonin, glucosamine/chondroitin, Aloe Vera, Guggul, glutamine, amino acids (e.g, arginine, isoleucine, leucine, lysine, methionine, phenylanine, threonine, tryptophan, and valine), green tea, lycopene, whole foods, food additives, herbs, phytonutrients, antioxidants, flavonoid constituents of fruits, evening primrose oil, flax seeds, fish and marine animal oils, and probiotics. NanoMill® (Elan Drug Delivery, hie.) equipped with a 18 cc batch chamber. As used herein, "about" will be understood by persons of ordinary skill in the art and will vary to some extent on the context in which it is used. Moreover, the invention is directed to fluticasone compositions which can be sterile filtered.
Antidiabetic herbal formulation for adrenal fatigue organic supplements
Such compositions are useful, for example, for oral, nasal, or topical applications. Such biorelevant aqueous media can be Attorney Docket No. H extremes. The present invention is described herein using several definitions, as set forth below and throughout the application. FLOVEΝT® (Glaxo SmithKline) is an oral inhalation aerosol of a microcrystalline suspension of fluticasone propionate (44 meg, 110 meg, or 220 meg) in a mixture of two chlorofluorocarbon propellants (trichlorofluoromethane and dichlorodifluoromethane) with lecithin. It is emphasized that 'therapeutically effective amount,' administered to a particular subject in a particular instance will not always be effective in treating the diseases described herein, even though such dosage is deemed a "therapeutically effective amount" by those skilled in the art. The fluticasone particles can be reduced in size in the presence of at least one surface stabilizer. The composition of any one of claims 1-5 further comprising one or more pharmaceutically acceptable excipients, carriers, or a combination thereof. Other types of genetic disorders may be caused by a antidiabetic drugs, or herbs or supplements with is a hormone that is produced by the adrenal Fluticasone propionate is marketed in several different commercial forms. The composition of any one of claims 1-7, wherein the at least one surface stabilizer is present in an amount selected from the group consisting of from about 0.5% to about 99.999%, from about 5.0% to about 99.9%, and from about 10% to about 99.5%, by weight, based on the total combined dry weight of the fluticasone and at least one surface stabilizer, not including other excipients. For example, such conventional non-toxic salts include those derived from inorganic acids such as hydrochloric, hydrobromic, sulfuric, sulfamic, phosphoric, nitric, and the like; and the salts prepared from organic acids such as acetic, propionic, succinic, glycolic, stearic, lactic, malic, tartaric, citric, ascorbic, pamoic, maleic, hydroxymaleic, phenylacetic, glutamic, benzoic, salicylic, sulfanilic, 2-acetoxybenzoic, fumaric, toluenesulfonic, methanesulfonic, ethane disulfonic, oxalic, isethionic, and the like. It may also be desirable to include isotonic agents, such as sugars, sodium chloride, and the like. China Millman The buzzword: Potassium The expert: Elena Kuklina, M. D, Ph. D, a nutritional epidemiologist with the U. S. Centers for Disease Control and Id. Due to the low bioavailability by the intranasal route, the majority of the pharmacokinetic data was obtained via other routes of administration. Res, 14 (4): 497-502 (1997). A mixture of 5% w/w fluticasone propionate and 2% lysozyme was milled for 30 min. In other embodiments of the invention, the sterile filterable nanoparticulate fluticasone compositions have an effective average particle size of less than about 140 nm, less than about 130 nm, less than about 120 nm, less than about 110 nm, less than about 100 nm, less than about 90 nm, less than about 80 nm, less than about 70 nm, less than about 60 nm, or less than about 50 nm. Ask the Herbalist. natural answers I want to use organic horseradish for repeating topical I have a couple of questions about herbal supplements. Is it Use of a fluticasone composition according to any one of claims 1 to 38 for preparation of a medicament. This is a method of preparing stable dispersions of poorly soluble active agents in the presence of one or more surface stabilizers and one or more colloid stability enhancing surface active agents free of any trace toxic solvents or solubilized heavy metal impurities. Exemplary emulsifiers are ethyl alcohol, isopropyl alcohol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propyleneglycol, 1,3-butyleneglycol, dimethylformamide, oils, such as cottonseed oil, groundnut oil, corn germ oil, olive oil, castor oil, and sesame oil, glycerol, Attorney Docket No. The non-fluticasone active agents can be present in a crystalline phase, an amorphous phase, a semi-crystalline phase, a semi-amorphous phase, or a mixture thereof. Id. at 1530. Studies using oral dosing of labeled and unlabeled conventional fluticasone propionate have demonstrated that the oral systemic bio availability of fluticasone propionate is negligible (<1%), primarily due to incomplete absorption and presystemic metabolism in the gut and liver. The use of claim 45, wherein the medicament is useful in treating a subject in need of either symptomatic or prophylactic treatment with a fluticasone composition. The composition of any one of claims 23-31, wherein the surface stabilizer is selected from the group consisting of an anionic surface stabilizer, a cationic surface stabilizer, a zwitterionic surface stabilizer, and an ionic surface stabilizer. Id. at 1521. (etc) The composition of claim 23 or claims 24, wherein at least about 70%, at least about 80%>, at least about 90%, at least about 95%>, at least about 99%o, or at least about 99.9%) of the fluticasone particles by weight have a particle size of less than the effective average particle size. Original Formulations Herbal Adrenal Support supplement provides focused natural support for your health when you are experiencing stress, adrenal fatigue, A supercritical fluid modifier (or co-solvent) is a chemical which, when added to a supercritical fluid, changes the intrinsic properties of the supercritical fluid in or around the critical point. When administered in an aerosol, fluticasone propionate acts locally in the lung; therefore, plasma levels do not predict therapeutic effect. Side effects associated with inhalation therapy are primarily oropharyngeal candidiasis and dysphonia (due to atrophy of laryngeal muscles). The liquid formulations of this invention can be formulated for dosages in any volume but preferably equivalent or smaller volumes than a liquid dosage form of a conventional non-nanoparticulate fluticasone composition. It is believed that this chemical form of bioadhesion is primarily responsible for the bioadhesive properties of the fluticasone compositions described herein.
If the nanoparticulate fluticasone composition additionally comprises one or more non-fluticasone nanoparticulate active agents, then such active agents have an effective average particle size of less than about 2000 nm (i.e, 2 microns), h other embodiments of the invention, the nanoparticulate non-fluticasone active agents can have an effective average particle size of less than about 1900 nm, less than about 1800 mn, less than about 1700 nm, less than about 1600 nm, less than about 1500 nm, less than about 1400 nm, less than about 1300 mn, less than about 1200 nm, less than about 1100 nm, less than about 1000 nm, less than about 900 mn, less than about 800 nm, less than about 700 nm, less than about 600 nm, less than about 500 nm, less than about 400 nm, less than about 300 nm, less than about 250 nm, less than about 200 nm, less than about 150 nm, less than about 100 nm, less than about 75 nm, or less than about 50 nm, as measured by the above-noted techniques. Thus, it is intended that the present invention cover the modifications and variations of this invention provided they come within the scope of the appended claims and their equivalents. Nutraceuticals and dietary supplements also include bio-engineered foods genetically engineered to have a desired property, also known as "pharmafoods." Attorney Docket No. Breast of the adrenal, Qarshi herbals for low thyroid - Herbal Health Supplements organic products, food supplements, herbal formulations, Both the foregoing general description and the following detailed description are exemplary and explanatory and are intended to provide further explanation of the invention as claimed. The compound has potent anti-inflammatory activity and is particularly useful for the treatment of respiratory disorders, particularly astlima. See e.g, Lindahl et al, "Characterization of Fluids from the Stomach and Proximal Jejunum in Men and Women," Pharm. Large amounts of unmiUed drug were seen in a photomicrograph. S. Patent Nos. Where a nanoparticulate fluticasone composition is co- formulated with a second active agent, the second active agent can be formulated in any suitable manner, such as immediate-release, rapid-onset, sustained-release, or dual-release form. Best pills for diabetes 2 and itching Particle size analysis of the milled fluticasone propionate composition, conducted using a Horiba LA-910 particle size analyzer (Irvine, CA), showed a final fluticasone Attorney Docket No. Administration by inhalation of corticosteroids, compared with oral administration, is preferable as this mode of administration reduces the risk of systemic side effects.
Methods for Targeting Drug Delivery to the Upper and/or Lower Gastrointestinal Tract," 6,582,285 for "Apparatus for Sanitary Wet Milling," 6,592,903 for "Nanoparticulate Dispersions Comprising a Synergistic Combination of a Polymeric Surface Stabilizer and Dioctyl Sodium Sulfosuccinate," and 6,656,504 for "Nanoparticulate Compositions Comprising Amorphous Cyclosporine and Methods of Making and Using Such Compositions," all of which are specifically incorporated by reference. The composition of any one of claims 1-10, wherein the at least one surface stabilizer is selected from the group consisting of cetyl pyridinium chloride, gelatin, casein, phosphatides, dextran, glycerol, gum acacia, cholesterol, tragacanth, stearic acid, benzalkonium chloride, calcium stearate, glycerol monostearate, cetostearyl alcohol, cetomacrogol emulsifying wax, sorbitan esters, polyoxyethylene alkyl ethers, Attorney Docket No. NanoMill® (Elan Drug Delivery, Inc.) equipped with a 18 cc batch chamber. A mixture of 5% w/w fluticasone propionate and 2% tyloxapol in saline was milled for 40 min. The surface stabilizers adsorb to or associate with the surface of the fluticasone particles. Richmond, Cationic Surfactants: Organic Chemistry, (Marcel Dekker, 1990). http://serioussoundzz.ning.com/profiles/blogs/anti-diabetes-fruit-quest First, particle sizes of less than 1 micron are desirable, as smaller particle sizes can be associated with a more rapid dissolution upon administration, and consequent faster onset of action as well as greater bioavailability. Al, published on January 31, 2002, for "Controlled Release Nanoparticulate Compositions," and WO 02/098565 for "System and Method for Milling Materials," describe nanoparticulate active agent compositions, and are specifically incorporated by reference. adrenal fatigue or adrenal exhaustion with Herbal Therapy: Look to Yin Valley formula and Herbs Organic Chinese Herbal Supplements The invention encompasses the nanoparticulate fluticasone compositions of the invention formulated or co-administered with one or more non-fluticasone active agents, which are either conventional (solubilized or microparticulate) or nanoparticulate. ADVAIR DISKUS® (GlaxoSmithKline, Research Triangle Park, NC) is an inhalation powder of a combination of microfine fluticasone propionate and salmeterol xinofoate, which is a highly selective beta2-adrenergic bronchodilator. The pharmaceutical compositions preferably comprise fluticasone, at least one surface stabilizer, and at least one pharmaceutically acceptable carrier, as well as any desired excipients. By "an effective average particle size of less than about 2000 nm" it is meant that at least 50%> of the nanoparticulate fluticasone particles or nanoparticulate non-fluticasone active agent particles have a particle size of less than about 2000 nm, when measured by Attorney Docket No.
Each actuation of the inhaler delivers 50, 125, or 250 meg of fluticasone propionate from the valve, and 44, 110, or 220 meg, respectively, of fluticasone Attorney Docket No. Therapeutically effective amount' as used herein with respect to a fluticasone dosage, shall mean that dosage that provides the specific pharmacological response for which the drug is administered in a significant number of subjects in need of such treatment. Crohn's disease and ulcerative colitis. A nutraceutical or dietary supplement, also known as a phytochemical or functional food, is generally any one of a class of dietary supplements, vitamins, minerals, herbs, or healing foods that have medical or pharmaceutical effects on the body. Non-nanoparticulate active agents have an effective average particle size of greater than about 2 microns, meaning that at least 50%) of the active agent particles have a size greater than about 2 microns. organic or wildcrafted herbs blend of natural supplements and herbs that show with natural herbs. Men's Herbal Remedies Chinese herbs The one or more surface stabilizers can be contacted with fluticasone either before, during, or after size reduction of the fluticasone. The viscosities of liquid dosage forms of nanoparticulate fluticasone according to the invention are preferably less than about 1/200, less than about 1/175, less than about 1/150, less than about 1/125, less than about 1/100, less than about 1/75, less than about 1/50, or less than about 1/25 of a liquid oral dosage form of a conventional, non- nanoparticulate fluticasone composition, at about the same concentration per ml of fluticasone. Glucolon diabetes sugar Besides such inert diluents, the composition can also include adjuvants, such as wetting agents, emulsifying and suspending agents, sweetening, flavoring, and perfuming agents. Examples of sweeteners are any natural or artificial sweetener, such as sucrose, xylitol, sodium saccharin, cyclamate, aspartame, and acsulfame. Redispersibility can be tested using any suitable means known in the art. Patients, and in some cases healthcare providers as well, are not fully aware of the health risks Herbal Product-Drug Interactions from a Pharmacological Perspective. the compound responsible for the herbal formulation's Supplements, and Herbal Inflammation and/or other disease processes in the skin increase percutaneous absorption. Cross and E.
NanoMill® (Elan Drug Delivery, h e; see U. Oral corticosteroids cause atrophy of the dermis with thin skin, striae, and ecchymoses but inhaled corticosteroids do not cause similar changes in the respiratory tract. Fluticasone propionate is described and claimed in British Patent No. The fluticasone of the invention can be in a crystalline phase, an amorphous phase, a semi-crystalline phase, a semi-amorphous phase, or a mixture thereof. Other compounds, such as a diluent, can be added to the fluticasone/surface stabilizer composition either before, during, or after the size reduction process. Representative examples of other useful surface stabilizers include hypromeilose (previously known as hydroxypropyl methylcellulose or HPMC), hydroxypropylcellulose, polyvinylpyrrolidone, sodium lauryl sulfate, dioctylsulfosuccinate, gelatin, casein, lecithin (phosphatides), dextran, gum acacia, cholesterol, tragacanth, stearic acid, benzalkonium chloride, calcium stearate, glycerol monostearate, cetostearyl alcohol, cetomacrogol emulsifying wax, sorbitan esters, polyoxyethylene alkyl ethers (e.g, macrogol ethers such as cetomacrogol 1000), polyoxyethylene castor oil derivatives, polyoxyethylene sorbitan fatty acid esters (e.g, the commercially available Tweens" such as e.g, Tween 20 ' and Tween 80® (ICI Speciality Chemicals)); polyethylene glycols (e.g, Carbowaxs 3550® and 934® (Union Carbide)), polyoxyethylene stearates, colloidal silicon dioxide, phosphates, carboxymethylcellulose calcium, carboxymethylcellulose sodium, methylcellulose, hydroxyethylcellulose, hypromeilose phthalate, noncrystalline cellulose, magnesium Attorney Docket No. Click here. probiotics and herbal supplements can make an enormous difference in the successful treatment of Adrenal Fatigue. Supplements For Adrenal Fatigue. Examples of preservatives are potassium sorbate, methylparaben, propylparaben, benzoic acid and its salts, other esters of parahydroxybenzoic acid such as butylparaben, alcohols such as ethyl or benzyl alcohol, phenolic compounds such as phenol, or quarternary compounds such as benzalkonium chloride. The anti-stress properties of Panax Ginseng (anti-fatigue and et al Antidiabetic effects of Panax ginseng berry extract gigas-containing herbal formulation: CUTIVATE® (GlaxoSmithKline) is a topical dermatological fluticasone propionate cream or ointment (0.05% and 0.005% concentration). The composition of any one of claims 1-10, wherein the surface stabilizer is a cationic nonpolymeric compound selected from the group consisting of benzalkonium chloride, a carbonium compound, a phosphonium compound, an oxonium compound, a halonium compound, a cationic organometallic compound, a quartemary phosphorous compound, a pyridinium compound, an anilinium compound, an ammonium compound, a hydroxylammomum compound, a primary ammonium compound, a secondary ammonium compound, a tertiary ammonium compound, behenalkonium chloride, benzethonium chloride, cetylpyridinium chloride, behentrimonium chloride, lauralkonium chloride, cetalkonium chloride, cetrimonium bromide, cetrimonium chloride, cethylamine hydro fluoride, chlorallylmethenamine chloride (Quaternium-15), distearyldimonium chloride (Quatemium-5), dodecyl dimethyl ethylbenzyl ammonium chloride(Quaternium- 14), Quaternium-22, Quaternium-26, Quaternium-18 hectorite, dimethylaminoethylchloride hydrochloride, cysteine hydrochloride, diethanolammonium POE (10) oletyl ether phosphate, diethanolammonium POE (3)oleyl ether phosphate, tallow alkonium chloride, dimethyl dioctadecylammoniumbentonite, stearalkonium chloride, domiphen bromide, denatonium benzoate, myristalkonium chloride, laurtrimonium chloride, ethylenediamine dihydrochloride, guanidine hydrochloride, pyridoxine HC1, iofetamine hydrochloride, meglumine hydrochloride, methylbenzethonium chloride, myrtrimonium bromide, oleyltrimonium chloride, Attorney Docket No.
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